Abstract : Fast dissolving tablets are gaining prominence as new drug delivery systems. Here, in this study venlafaxine HCl is taken as the model drug to convert in to fast dissolving tablet using combination of natural disintegrating agent. Venlafaxine HCl is commonly used as antidepressant, has poor bioavailability due to extensive first pass metabolism. The aim of the study is to fast relief against the depression. The fast dissolving tablet was prepared by various natural disintegrating agent like Treated agar and Isapghula husk powder. A 32 Full Factorial Design was applied to investigate the combine effect of Treated agar and Isapghula husk powder. Disintegrating time, wetting time and in vitro drug release taken as response variables. The prepared tablets were evaluated for in vitro dissolution, friability, hardness and weight variation. All blends were compatible by evaluating them on FTIR study. No drug-excipients interaction was found. Tablets were showing faster disintegration within seconds and Statistic analysis software showed that batch FB10 was found to be optimized as it had almost identical dissolution profile. Optimized batch FB10 was conducted at accelerated conditions for one month and it was found to be stable.
Keyword : Isapghula husk, Fast dissolving tablets, Venlafaxine HCl
Abstract : The Aim of the present investigation was to formulate and evaluate Valsartan transdermal drug delivery system. A 32 full factorial design was employed to explore the effects of HPMC K4M and Polyvinyl Pyrrolidine (independent variables) on Tensile strength, % cumulative drug release at 6 hours and % cumulative drug release at 24 hours(Dependent variables). Drug-polymer compatibility studies was determined by Fourier Transform Infrared Spectroscopy. The result of compatibility study revealed that there was no interaction between drug and polymers. Results showed drug release in the range 78.73± 0.38 - 96.32±0.33 and drug content in the range of 95.49±0.444 - 98.40 ±1.21. Moisture content and moisture uptake were increased for patches containing higher amount of HPMC K4M. Patch containing HPMC K4M in higher proportion gives increase in the drug release. It indicates that as PVP K30 increase drug release was decreased. On the basis of In-Vitro drug release performance F9 was selected as the optimized formulation. Ex-vivo drug release study carried out for optimized batch and it showed 96.32±0.33 % drug release after 24 hours. F9 shows ideal higuchi release kinetic. Skin irritation study for F9 revealed that it was free of irritation. Optimized batch F9 was found to the stable at 40 ± 0.5 °C and 75 ± 5% RH during the test period of 1month.