Abstract : Chronotherapeutics also known as pulsatile drug delivery system deals with the study of the temporal changes in absorption, distribution, metabolism and elimination of drugs and thus takes into account the influence of time of administration on these different steps and it focuses on the release of a drug after a lag time at a particular site in order to maintain constant blood levels of a particular drug matching circadian rhythms of various diseases. The role of circadian rhythms in the mechanisms of disease and the pharmacokinetics and pharmacodynamics of medications constitutes a challenge to drug-discovery and drug-delivery scientists. The aim of present work is to develop chrono modulated compress coated floating tablets of Divalproex Sodium in the treatment of partial epilepsy

Keyword : Chronotherapeutics, Drug delivery, pulsatile drug delivery systems , Divalproex Sodium, compress coated floating tablets.