Abstract : ABSTRACT
Semicarbazone and thiosemicarbazones are one of the most widely used organic compounds that can interact with metal to form complexes. Their complexes exhibit a broad range of biological activities, including antiviral, fungicidal, antiparasital, antibacterial, antitumor and antimalarial activities. Stability constant is an important determinant factor for the properties of metal-ligand interactions in biological system. Protonation constants which are important physicochemical parameters can provide critical information about semicarbazone and thiosemicarbazone metal complexes as drug properties such as solubility, lipophilicity, acidity, basicity, transport behavior, bonding to receptors, and permeability natures. This review summarizes recent works on the biological activities of semicarbazone and thiosemicarbazone metal complexes and their stability constant.
Keywords: Semicarbazone , Thiosemicarbazone, Metal Complexes, Biological Activities, Stability constant