Abstract : ABSTRACT Malaria is one of the major public health problems worldwide affecting around 91countries and territories. Use of insecticide-treated nets (ITNs) is one of the key components of malaria prevention and control as recommended by the World Health Organization (WHO). Thus, in this paper, we aim to summarize the evidence whether utilization of ITN is related to malaria illness through a systematic review and meta-analysis approach. Two investigators identified articles through data base searching of PubMed, SCOPUS, Google Scholar, Web of Science and MEDLINE from February1 to February 26 2021. Two reviewers were worked data extraction and quality assessment of studies. We include study if the study Newcastle Ottawa Scale score is 5 or greater. A random -effects model was used to estimate the pooled ORs with 95% CIs because there was evidence of heterogeneity.13 studies comprising 6969 participants, 2187 of which had malaria illness were included in the quantitative syntheses (meta-analyses). The pooled odds ratios for all studies revealed no statistically significant association of malaria illness with ITN users relative to ITN non users OR 0.69 (95%CI 0.44 to 1.10), P = 0.12, I2= 92%) There was significant heterogeneity for all studies ( Q = 142.29; P = 0.12; 𝐼2 =92%. No publication bias was observed (Egger’s test: 𝑃 = 0.098, Begg’s test: 𝑃 = 0.329). In this study the prevalence of malaria was low among those with ITN users than among those without ITN use (14.58% vs. 16.80%), although the difference was not significant Thus, longitudinal studies are recommended in order to study peoples utilization behavior of ITN as well effectiveness of ITN in preventing malaria in the future Keywords: Insecticide treated net, Meta-Analysis, malaria, Systematic Reviews

Keyword : Insecticide treated net, Meta-Analysis, malaria, Systematic Reviews