Abstract : Chalcones have been reported to present various biological activities such as anti-inflammatory, antioxidant, antitubercular, antibacterial activities. It is a basic moiety of many heterocyclic systems containing oxygen, sulphur and nitrogen. Nitrogen containing heterocyclic derivatives synthesized from Chalcones have exhibited anti-inflammatory, anticancer and antimicrobial activities. An attempt has been made to synthesize Chalcones by the reaction of 3-acetyl-2,5-dimethylfuran with various aromatic and heteroaromatic aldehydes. Further, Chalcones derivatives were cyclised to 2-pyrazoline analogs by phenyl hydrazine in absolute ethanol in the presence of pyridine. The newly synthesized Pyrazoline derivatives have been characterized by IR, 1HNMR,Mass spectra and elemental analysis and evaluated for their analgesic, anti-inflammatory, antifungal and antibacterial activities. It was found that compounds having 3,4,5-trimethoxyphenyl ring and 4-methoxyphenyl ring at the 5-position of the 2-pyrazoline ring possessed the maximum analgesic activity, moreover it has also exhibited good antifungal and antibacterial activities.

Keyword : Chalcones, 2-Pyrazolines, analgesic activity, antifungal activity, antibacterial activity.