Abstract : The University an academic institution of higher learning is a place where students engage in the struggle to attain academic excellence, professional success and a secure future. This study aimed to analyse the relationship between headache and smoking in nursing students. Descriptive design used to achieve the objectives of the study was carried out at on students of Nursing college at Duhok University from September 1st, 2017 to May 1st, 2018. The study was conducted in Duhok university. A sample consisted of (80) students who were study in the college. In order to collect the study information, a questionnaire was constructed. The questionnaire consists of two parts, part I demographic data which is composed of (5) items [age, gender, marital status, residential area, & class], while part II is composed of (5) items [Headache Frequency, Onset, Location, smoke cigarette, & number of cigarettes] Data were analyzed by using descriptive statistics, which include frequency and percentages, Statistical Package for Social Science (SPSS) version (24) is used for data analysis. A total of 80 male students were evaluated in the study. Regarding smoking 79 (98.75%), while only 1 dose not smoke (1.25%).The prevalence of headache among the smokers was seen in 70 (88.6%) and without headache in 9 (11.4%) students. Headache is a chronic disease that negatively affects a student’s quality of life. This study was undertaken to show the effect of smoking on headache frequency.