Abstract : The present work aims to develop and evaluate buccal tablets of Nebivolol Hydrochloride. Tablets of Nebivolol Hydrochloride were prepared by direct compression method using bioadhesive polymers like Chitosan, Guargum, Xanthan gum in different ratios. The tablets were evaluated for pre and post compression parameters and found to be within the limits. The tablets were evaluated for in vitro release in pH 6.8 phosphate buffer for 8 hr in standard dissolution apparatus. In order to determine the mode of release, the data was subjected to Zero order, first order, Higuchi, Korsmeyer and Peppas diffusion model. The formulation F3 showed maximum drug release (89.06%) in 8 hrs. The optimized formulation F3 showed a surface pH of 6.18 and was following Zero order mechanism with regression value of 0.981. FT-IR studies revealed the absence of any chemical interaction between drug and polymers used.