Abstract : The synthesis of nanostructured substances, specifically metal nanoparticles, has accrued utmost concern over the last decade owing to their particular properties that cause them to applicable in distinctive fields of technology era. The challenge to the usage of these nanoparticles is the paucity of an effective technique of synthesis so one can produce homogeneous size and form nanoparticles in addition to debris with limited or no toxicity to the human health and the surroundings. The biological technique of nanoparticle synthesis is a relatively easy, reasonably-priced, and environmentally friendly approaches than the conventional chemical technique of synthesis and accordingly profits a top hand. The bio mineralization of nanoparticles in protein cages is one among such biological approaches used inside the era of nanoparticles. This technique of synthesis apart from being a more secure approach inside the production of nanoparticles is also able to control particle morphology.